Scientist - Image Analyst at Allen Institute (Seattle, WA)

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To apply, please visit http://www.alleninstitute.org/careers/

About the Allen Institute for Cell Science

The goal of the Allen Institute for Cell Science is to advance understanding of cell behavior in its normal, pathological, and regenerative contexts. The Institute, located in Seattle, Washington, employs a multi-disciplinary team approach to generate novel cellular reagents, models, and databases that are informed by and open to the community. The Institute aims to understand cells, individually and in collectives, as an integrated system of organelles, molecular machines, and regulatory complexes that are repurposed and specialized to generate the plethora of observed cellular behaviors. It will do this using human induced pluripotent stem cells (hiPSCs), gene editing, and live cell imaging, developing predictive models and theory, and creating a novel multi-scale, dynamic and visual output for the experiments and models.

Position Summary
The goal of the Image-based Assay Development team is to develop and implement a pipeline of image-based assays of cell organization, activity, and function. This Scientist level position is part of a team that develops image-based assays of cellular organization and activities that are amenable to scale-up and integration into a live-cell high-throughput microscopy pipeline. The focus of this position is on image processing, feature extraction, and image analysis activities. S/he may be required to supervise the activities of others and will work collaboratively with the Institute’s technical and programmatic teams.

Job Responsibilities

• Develop and implement robust image processing pipelines, algorithms, feature extraction, and protocols for reproducible image-based assays of cell organization, dynamics, activities, and function
• Collaborate with other teams in the institute to scale-up image processing protocols into a high throughput microscopy pipeline
• Maintain rigorous quality control standards
• Maintain meticulous records and work closely with other scientists to coordinate complex experiments
• Adherence to SOPs, GLPs and regulatory requirements
• Contribute to the implementation of an image management system
• Coordinate with other programs in the Institute to ensure seamless integration and sharing of resources and data
• Prepare written summaries and present activities internally and publicly

Basic Qualifications

• PhD in a biological science (e.g. cell biology, biophysics, bioengineering), physical science, or related science or engineering field
• Extensive experience in image processing and analysis
• Experience in image-based cell biology assays; some experimental experience would be an advantage
• Experience in 3D image processing and segmentation preferred
• Experience with machine learning approaches would be an advantage
• Experience in a range of light microscopy modalities (especially 3D confocal and spinning disk microscopes) would be an advantage
• Careful attention to detail and excellent interpersonal skills
• Experience working in a multi-disciplinary environment in academic or industrial settings
• Ability to work independently and in a collaborative, multidisciplinary environment

Communication Skills

Ability to read, analyze, and interpret general business periodicals, professional journals, technical procedures/reports/documents, or governmental regulations. Ability to write reports and business correspondence and speak effectively in front of groups of employees and external populations.

Reasoning and/or critical thinking ability
The ability to define problems, collect data, establish facts, and draw valid conclusions. Ability to interpret an extensive variety of technical instruction. Constructive thinking and alternative short- to long-term solutions must be considered. Action plans must be developed and implemented.

Computer Skills
Advanced ability to operate computers and related software programs. Strong computer programming skills. Knowledge of Python would be an advantage.

PHYSICAL REQUIREMENTS AND WORK ENVIRONMENT

Frequent exposure to potentially hazardous conditions that may result in the threat of health and safety including extreme noise, or temperature changes, climbing and lifting, chemicals and other hazardous materials, and machinery.

To apply, please visit http://www.alleninstitute.org/careers/